BRAIN

Heptanoate as a neural fuel: energetic and neurotransmitter precursors in normal and glucose transporter I-deficient (G1D) brain

Isaac Marin-Valencia¹, Levi B Good¹, Qian Ma¹, Craig R Malloy^2,3,4 and Juan M Pascual^1,5,6

1. ¹Rare Brain Disorders Clinic and Laboratory, Department of Neurology and Neurotherapeutics, Dallas, Texas, USA
2. ²Department of Radiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
3. ³Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
4. ⁴Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
5. ⁵Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
6. ⁶Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, Texas, USA

Correspondence: Professor JM Pascual, Rare Brain Disorders Clinic and Laboratory, Department of Neurology and Neurotherapeutics, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8813, USA. E-mail: Juan.Pascual@UTSouthwestwern.edu

Received 25 April 2012; Revised 27 August 2012; Accepted 3 September 2012
Advance online publication 17 October 2012

This study was supported by Fundación Caja Madrid (IMV) and NIH Grants NS077015 (JMP), RR002584 and EB000461 (CRM, JMP), F32NS065640 (LBG), and Dallas Women’s Foundation (Billingsley Fund) (JMP